a Record control number WOS:000258833800028

a ISSN 0163-2116

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number WI140

b Item number .J35 2008

a Personal name Bayraktar, Yusuf.

h Medium Electronic Document

a Title JAK2V617F mutation in patients with portal vein thrombosis

c Statement of responsibility, etc Yusuf Bayraktar, Ozgur Harmanci, Yahya Buyukasik, Ali Ibrahim Shorbagi, Aysegul Hasegeli Sungur, Cemaliye Akyerli Boylu, Aytemiz Gurgey, Ferhun Balkanci.

b Name of publisher, distributor, etc Springer,

c Date of publication, distribution, etc 2008.

a Summary, etc In a retrospective cohort, we investigated the presence of the JAK2V617F mutation in chronic non-cirrhotic portal vein thrombosis (PVT) patients, irrespective of the presence or absence of myeloproliferative diseases (MPDs). We identified 25 patients in whom thrombophilia workup was completed. The diagnoses of MPDs were made according to the World Health Organization (WHO) criteria. JAK2V617F mutation analysis was performed by allele-specific polymerase chain reaction (PCR). There were 9 male and 16 female patients. Prior to JAK2V617F analysis, there were one or more thrombophilic risk factors in 19 patients (76%). The JAK2V617F mutation analysis revealed the presence of this mutation (all in the heterozygote state) in six patients (24%; two male, four female). Five of the six cases with prior clinical diagnosis of MPDs were found to have wild-type JAK2. We found that the addition of JAK2V617F analysis into the thrombophilia workup in patients with chronic PVT contributes to a 4% increase in the diagnosis of thrombophilic conditions.

a Topical term or geographic name as entry element Gastroenterology & Hepatology

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

g Relationship information OCT 2008, Vol. 53 Issue 10, p2778-2783

t Title Digestive diseases and sciences

x International Standard Serial Number 01632116

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1007/s10620-008-0225-y